| Some of these proposed interventions have limitations 125 or are in their infancy 75 | Mount Sinai School of Medicine |
|---|---|
| This natural increase in delta FosB or viral overexpression of delta FosB within the NAc modulates sexual performance, and NAc blockade of delta FosB attenuates this behavior Hedges et al, 2009; Pitchers et al | Depending on the level of severity, this disorder is classified as mild, moderate, or severe |
Despite the importance of numerous psychosocial factors, at its core, drug addiction involves a biological process: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use, that define a state of addiction.
7| Office of the Surgeon General | "Neurobiologic Advances from the Brain Disease Model of Addiction" |
|---|---|
| This syndrome is characterized by a medication-induced increase in or compulsive engagement in non-drug rewards such as gambling, shopping, or sex Evans et al, 2006; Aiken, 2007; Lader, 2008 | , the mesocorticolimbic system and extended amygdala as drugs of abuse Volkow et al, 2004 |
Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems, disability, and failure to meet major responsibilities at work, school, or home.